Kelsey Grammer
NBC//Getty ImagesAfter playing the role of Dr. Frasier Crane for over 250 episodes (now that’s a lot of acting), Grammar executive produced Kelsey Grammer Presents: The Sketch Show, appeared in the Fox TV series, Back to You for one season, and served as the executive producer for the Emmy-nominated series, Medium and Girlfriends. That’s not all, though—he's obviously front-and-center of the current revival.
2David Hyde Pierce
Chance Yeh//Getty ImagesMost known for playing Frasier’s brother, Niles, David Hyde Pierce went on to have an exciting career after the famous series ended. He had a recurring role in The Good Wife and acted in a handful of episodes in Julia, the HBO Max series about Julia Child. He’s also set to play Father Conor in the yet-to-be-released film, The Georgetown Project, which stars Russell Crowe and Sam Worthington.
3Jane Leeves
Fox//Getty ImagesWho could forget Jane Leeves’ Frasier character, the ever-so-sensible Daphne? Following the iconic show, Leeves took on a recurring role as Joy Scroggs in Hot in Cleveland from 2010 to 2015, and then in 2018, starred in the TV series, The Resident as Kit Voss.
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4Peri Gilpin
Michael Tullberg//Getty ImagesIf Roz from Frasier, played by Peri Gilpin, looks familiar, it’s because she’s been in several different movies, television shows, and shorts throughout recent years. To give you an idea: she’s appeared in Desperate Housewives, Law & Order: Criminal Intent, Broad City, and Grey’s Anatomy. In the late 2000s, she took on a more regular role in Make It or Break It, an ABC Family series centered around a group of teen gymnasts. Her most recent work includes playing Sara Hughes in the Netflix original, The Anthrax Attacks.
5Bebe Neuwirth
Dia Dipasupil//Getty ImagesYou may remember Bebe Neuwirth as Dr. Lilith Sternin, Frasier Crane’s ex-wife. However, Frasier isn’t the only series this actress has appeared on. Following her role on the hit series, Neuwirth appeared in an episode of Will & Grace, had a recurring role on Law & Order: Trial By Jury in 2005, and later starred in Madam Secretary as Nadine Tolliver. In 2019, she graced the big screen in Jumanji as Nora, and a couple of years later had a role in tick, tick…BOOM! Even better? In 2022 she reunited with her Frasier co-star, David Hyde Pierce, in Julia.
6Jean Smart
Gilbert Flores//Getty ImagesJean Smart acted in seven episodes of Frasier as Lana Gardner, Frasier’s former classmate whom he once had a crush on. After her run on the award-winning show, she appeared in other series, including Center of the Universe, 24, Samantha Who?, Legion, Mare of Easttown, and Hacks. She also played Carol in the 2004 cult classic Garden State.
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7Dan Butler
Nicholas Hunt//Getty ImagesDan Butler, who played radio host Bob “Bulldog” Briscoe on the show, also voiced multiple characters in Hey Arnold! in more than 30 episodes through the years. Besides his voice work, he also acted in Blue Bloods, House, and The Mist, and most recently had a role in the Marilyn Monroe-inspired movie, Blonde.
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